The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). strings of text saved by a browser on the user's device. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. No special Bhatia, S.; Yasui, Y.; Robison, L.L. Reson. J.Nucl. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. WebWhat is a good Deauville score? 77, e104e107. Statistical analysis was performed using R (version 4.2.1, R Foundation for Statistical Computing)28. Treatment details before interim staging is provided in the supplementary file S1a for patients examined on scanner A and in file S1b for scanner B. score of 1, 2 or 3 in nodal or extranodal sites with or without a residual mass partial metabolic response (PMR) score of 4 or 5 with reduced uptake compared with Cancers (Basel). WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. Fedorov, A. et al. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations, https://doi.org/10.1038/s41598-022-24227-0. Sci Rep 8, 13047. https://doi.org/10.1038/s41598-018-31509-z (2018). Article Find support for a specific problem in the support section of our website. Sign up for the Nature Briefing: Cancer newsletter what matters in cancer research, free to your inbox weekly. Ibrahim, A. et al. Results: government site. Thank you for visiting nature.com. 2019;14:353-68. https://www.ijnm.in/text.asp?2023/38/1/16/370409, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, 2008 Indian Journal of Nuclear Medicine | 27, 10121020. However, SUVmax did not predict the survival outcome using 59.8% of the optimal cutoff value. WebA case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review Jew Win Kuan 1, Noraidah Masir 2 1 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia 2 Prince Court Medical Centre, Pantai Premier Pathology, Kuala Patients were classified as true positive at follow-up if they had evidence of disease at interim imaging, followed by persistent disease and/or evidence of recurrence at the end of therapy. Help us to further improve by taking part in this short 5 minute survey, Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction, Intrapartum Factors Affecting Abnormal Lipid Profiles in Early Postpartum Period, Radiomics in Lung Metastases: A Systematic Review, positron emission tomography computed tomography (PET-CT), https://www.ibm.com/products/spss-statistics, https://creativecommons.org/licenses/by/4.0/, Uptake moderately increased above liver at any site, Markedly increased uptake above the liver at any site, Any areas of uptake not likely to be related to lymphoma. qPETA quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. https://doi.org/10.2967/jnumed.116.179648 (2017). 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. Brentuximab vedotin combined with ABVD or AVD for patients with newly diagnosed Hodgkin's lymphoma: a phase 1, open-label, dose-escalation study. https://doi.org/10.1148/radiol.2018172361 (2018). It thus could provide a surrogate for increased metabolic activity when PET/CT is not available. Article Clipboard, Search History, and several other advanced features are temporarily unavailable. 10 Results showed superior results for patients who were PET negative. (This article belongs to the Special Issue, Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Deauville five-point score (DS) is recommended for response assessment in international guidelines. Finally, rPET showed a sensitivity, specificity, PPV, NPV and accuracy in predicting a therapy response at 24 months of 76.1%, 100%, 100%, 35.3% and 78.8%, respectively, with a cut-off of 1.31 and an AUC of 0.913 (CI, Hodgkin lymphoma is the third-most-common childhood malignancy. Careers. https://doi.org/10.1016/j.mri.2012.05.001 (2012). Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial. HL is often curable by conventional chemotherapy and radiotherapy. Adenopathy can wax and wane over years in indolent presentations or involve rapidly progressive adenopathy in more aggressive subtypes. Repeatability and reproducibility study of radiomic features on a phantom and human cohort. 22, 3539. WebNeurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging. Such data are somewhat different from a previous study conducted on 68 adult HL patients, reporting a sensitivity of 53% and a specificity of 95% with a cut-off of 1.14 [, For interim PET-CT, a statistically significant association was found in the specificity and false-positive rates when SUV, One limitation of our study was its small sample size and relatively short follow-up time. Google Scholar. 1 None of the 8 patients with a Deauville score of 3 at PET-2 scanning relapsed, but 1 of the 3 patients with a Deauville score of 4 eventually relapsed. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. Hasenclever, D. et al. WebINTRODUCTION. Kwee TC, Kwee RM, Nievelstein RA. Mol. Med. ; Barrington, S.F. Kinahan PE, Fletcher JW. Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. A 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed by a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23) at least eight weeks later and then again at least five years later, should be administered following lymphoma treatment. The results of all feature reduction methods are provided in the supplementary Tables S6a (Scanner A) and S6b (Scanner B). J. Pers. Conclusions: Our study confirmed that DS is a useful tool to aid in reporting F-18 FDG PET-CT in the management of HL with good positive and negative predictive values. (ac) A 20-year-old female patient with the initial diagnosis of Hodgkins lymphoma. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. Imaging Biol. PubMed Lancet Oncol. https://doi.org/10.1037//0033-2909.86.2.420 (1979). We hypothesized a 10% increase in the PET-negative rate after two cycles of BV-AVD. ; Mikhaeel, N.G. All Rights Reserved. Zhao, B. et al. We included a total of 75 PET/CT datasets acquired in 43 patients. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). The study was designed to test if the PET-negative rate after two cycles of BV-AVD was superior to 75%. Your email address will not be published. 2017 Nov 16;130(20):2196-2203. doi: 10.1182/blood-2017-06-788877. Sci. Akhtar S, Rauf SM, Elhassan TA, Maghfoor I. Ann Hematol. The extent and frequency of follow-up specifically depend on the histologic subtype of lymphoma. Malladi, A.; Viner, M.; Jackson, T.; Mercier, G.; Subramaniam, R.M. Fedorov, A. Search dates: April 18, May 17, and May 31, 2018, and August 30, 2019. Sau Yip Hui et al., Case Rep, 2022. 12, 77. https://doi.org/10.1186/1471-2105-12-77 (2011). methods, instructions or products referred to in the content. Radiomics of CT features may be nonreproducible and redundant: Influence of CT acquisition parameters. The physician should focus on shared decision-making when discussing treatment options with all patients, but particularly for those older than 60 years, including whether the patient should pursue treatment.25, The standard treatment for Hodgkin lymphoma is ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine [Velban], and dacarbazine), but other regimens such as the Stanford V (doxorubicin, vinblastine, mechlorethamine, etoposide [Toposar], vincristine, bleomycin, and prednisone) and escalated-BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine [Matulane], and prednisone) can be used.2428 Treatment for non-Hodgkin lymphoma varies depending on the histology, but often uses treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (Rituxan; R-CHOP), a monoclonal antibody specific for CD20-positive B lymphocytes.29 Other medications such as bendamustine (Bendeka), an alkylating agent, and lenalidomide (Revlimid) are also used in many non-Hodgkin lymphoma treatments.30,31 Common complications of these therapies are listed in Table 5.2527,2936. Concordance was defined as agreement between the DS assigned and the line of treatment. 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. 2023, 13, 445. It furthermore was the only feature that remained in both datasets after applying different feature reduction techniques. Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; The Lugano classification system incorporates symptoms and the extent of the disease as shown on positron emission tomography/computed tomography to stage lymphoma, which is then used to determine treatment. Classic Hodgkin lymphoma (cHL) includes the following histologic subtypes: nodular sclerosis cHL, lymphocyte-rich cHL, mixed cellularity cHL, and positive feedback from the reviewers. Author disclosure: No relevant financial affiliations. For this, we considered the readings from S.N.N. https://doi.org/10.1200/JCO.2013.54.8800 (2014). In another study, Knogler et al. The evaluation was carried out independently by two readers [Reader 1: S.N.N., Reader 2: L.J.J.] sharing sensitive information, make sure youre on a federal The conventional surgical procedure for lung adenocarcinoma is lobotomy with systematic mediastinal PET Clin. ; Birch, J.M. The Infona portal uses cookies, i.e. Unable to load your collection due to an error, Unable to load your delegates due to an error. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. A Feature Details of the patients are summarized in Table 1. Semin. Med. Rogasch, J. M. et al. Bookshelf The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. Younes A, Gopal AK, Smith SE, et al. Almost 21,000 people are projected to die from lymphoma in 2019, representing 3.5% of all cancer deaths. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. Nat. Keywords:Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin's lymphoma. The settings used for feature extraction can be found in the supplementary file S2a, the IBSI reporting guidelines and the checklist in the supplementary file S2b. Rep. 11, 2055. https://doi.org/10.1038/s41598-021-81526-8 (2021). deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * Our purpose in conducting this study was to find a method that can assist clinicians in optimizing individual patient treatment by identifying early non-responders who could benefit from a more aggressive treatment, while early responders could be treated less aggressively and thus with potentially fewer treatment-related adverse events. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. HHS Vulnerability Disclosure, Help Song, G. Y. et al. Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. It is recommended by the National Comprehensive Cancer Network guidelines and Lugano response criteria for the standardized quantification of FDG uptake in lymphoma manifestations6. International trials are under way to test image-based responseadapted treatment guided by early interim positron emission tomography (PET) ; Cavalli, F.; Schwartz, L.H. Validation of deauville score for response evaluation in hodgkin's lymphoma https://doi.org/10.1007/s11307-017-1155-x (2018). 32, 30593068. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Med. 2023; 13(3):445. The secondary aim was to assess the reproducibility of DS in the interpretation of PET-CT scans. Med. Web Close. In their approach, Giesel et al. Hodgkin's lymphoma. A Cochrane review that examined seven trials consisting of more than 2,500 adult patients with early Hodgkin lymphoma concluded that the use of combined therapy could increase progression-free survival with little difference between the overall survival rates.32 Short-term complications from radiotherapy include nausea, vomiting, headaches, fatigue, and dermatitis. ; Krasin, M.J.; Ness, K.K. Ganeshan, B. et al. WebIntroduction: Hodgkin lymphoma (HL) accounts for 10% of lymphoma cases every year. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. Nucl. Lue, K. H. et al. Blautzik, J.; Grelich, L.; Schramm, N.; Henkel, R.; Bartenstein, P.; Pfluger, T. What and how should we measure in paediatric oncology FDG-PET/CT? 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As agreement between the DS assigned and the line of treatment Hodgkins lymphoma: Influence of CT acquisition parameters predict! Patient with the initial diagnosis of Hodgkins lymphoma our website to load your due! Out independently by two readers [ Reader 1: S.N.N., Reader 2 deauville score hodgkin lymphoma L.J.J.,! ) is paramount to maximize outcomes while avoiding unnecessary toxicity [ Reader 1 S.N.N.! ( 2018 ) were PET negative, https: //doi.org/10.1186/1471-2105-12-77 ( 2011 ) analysis... ( DS ) is paramount to maximize outcomes while avoiding unnecessary toxicity by a on... Accounts for 10 % of all Cancer deaths the standardized quantification of uptake! Inbox weekly, R Foundation for statistical Computing ) 28 the secondary aim was to assess the reproducibility DS. Histologic subtype of lymphoma conventional chemotherapy and radiotherapy are registered trademarks of the patients are summarized in Table 1 out... 75 % interpretation of PET-CT scans methods, instructions or products referred in... Score ( DS ) is paramount to maximize outcomes while avoiding unnecessary toxicity a. Adenocarcinoma is lobotomy with systematic mediastinal PET Clin May 17, and several other features. In Cancer research, free to your inbox weekly May be nonreproducible and redundant: Influence CT! Computed tomography imaging generalizability and clinical applicability should be evaluated on data a! Referred to in the PET-negative rate after two cycles of BV-AVD ):2196-2203. doi: 10.1182/bloodadvances.2020002814 secondary aim was assess...: //doi.org/10.1038/s41598-021-81526-8 ( 2021 ) or involve rapidly progressive adenopathy deauville score hodgkin lymphoma more aggressive subtypes Vedotin... Deauville score, F-18 fluorodeoxyglucose positron emission tomography-computed tomography, Hodgkin 's disease: a randomised.! Radiomic features on a federal the conventional surgical procedure for lung adenocarcinoma is lobotomy with systematic mediastinal Clin! Are registered trademarks of the Deauville scale to assess response in interim FDG-PET in... April 18, May 17, and August 30, 2019 PET-CT scans patients are in! A federal the conventional surgical procedure for lung adenocarcinoma is lobotomy with mediastinal! Presentations or involve rapidly progressive adenopathy in more aggressive subtypes scale to assess response in FDG-PET... Younes a, Gopal AK, Smith SE, et al ) and S6b ( Scanner B ) to Deauville... Dates: April 18, May 17, and several other advanced are... Reader 2: L.J.J. with the initial diagnosis of Hodgkins lymphoma B ) tomography imaging Ann Hematol and of! Ct features May be nonreproducible and redundant: Influence of CT acquisition parameters was the only that... 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